It is superior to copper sulfate, chloride & citrate: it is non-acidic, less toxic to fish, remains in solution, and does not contaminate the filter bed. It is superior to chelates: it is fully charged (ionic), active at low concentrations, and is removable with carbon.
Remove all invertebrates. Turn off UV sterilizer; remove chemical filtration. If the bottle has a dropper cap, use 20 drops (1 mL) per 40 L (10.5 gallons*) the first day, wait 48 hours, then repeat. On non-dropper caps, each inner ring is 1 mL. In freshwater use half dose. Final copper concentration is 0.5 mg/L (0.25 mg/L in freshwater). Leave at this concentration for 14 days. Do not redose without testing (MultiTest: Copper™). Do not use in conjunction with any other medication. Do not add reducing agents (e.g. dechlorinators, ammonia removers) to water treated with Cupramine™. If tank has ever been treated with an ionic copper (e.g. copper chloride, sulfate or citrate), test copper level after initial dosing. Although most fish tolerate Cupramine™ to 0.8 mg/L, it is not advisable to exceed 0.6 mg/L copper. Remove with carbon or CupriSorb™.
In case of eye exposure, promptly & thoroughly wash eyes with water & seek medical attention.